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In clinical trials, doses are escalated gradually over several weeks to improve tolerability a process known as dose titration

10.1002/lt.25929 99 NultyJ.AnandH.DhawanA

Ukelis U, Kramer P J, Olejniczak K and Mueller S O 2008 Replacement of in vivo acute oral toxicity studies by in vitro cytotoxicity methods: Opportunities, limits and regulatory status

The authors systematically evaluated conflicting findings regarding DSIP's sleep-promoting effects, noting that while initial studies showed dramatic increases in slow-wave sleep, subsequent research produced more variable results depending on species, administration route, and baseline sleep states