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Wang for assistance in data analysis, the Protein Chemistry and Proteomics Facility at Tsinghua University for assistance with proteomics assays and the Tsinghua University Center of Pharmaceutical Technology for assistance with metabolomics assays

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Iodoacetamide was added to 10 mM and incubated in the dark at room temperature for 30 min to alkylate the proteins

Nervup Injection is a supplement of Vitamin B12