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doi:10.3109/07420528.2014.957304

Advanced Glycation End-Products (AGE) Chronic hyperglycemia, such as in T2D, promotes a pro-inflammatory state that contributes to the glycation (non-enzymatic attachment of glucose) of proteins and lipids

Calcium phosphate deposition starts in the basement membrane, continues through the interstitium, mineralizing the collagen and membrane bound vesicles, until it reaches the papillary surface

Although the results could not be replicated by others, 180 15 years later Joseph Weiss 181 was able to achieve significant tumor growth inhibition in 20 out of 90 incurable cancer patients with a similar method