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Expected Timelines 4-8 Weeks Subtle changes in skin texture and firmness 8-12 Weeks Visible improvements in wrinkles and skin quality 12+ Weeks Optimal results with continued use Clinical evidence includes 12-week studies showing improved skin laxity, clarity, and reduced wrinkles, outperforming vitamin C and retinoic acid in comparative trials with 70% increase in skin elasticity after 12 weeks

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Dex modulates the balance of water-electrolyte metabolism by depressing the expression of AVP in PVN

The interpretation of the results of included studies should take into account the constitution of each elemental diet (Supplementary Table)