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Because it does not activate the hGH receptor (fully) and does not elevate IGF-1 in human trials, it avoids many of the growth-hormone-related side effects (such as insulin resistance) seen with full hGH therapy

PMID 16916826

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For example, people who maintain a vegetarian or vegan diet, people with absorption disorders, and those taking prescription meds like Metformin, Proton Pump Inhibitors (PPIs), and H2 blockers like Pepcid are often at greater risk