In addition to the copper-induced accumulation of lipoylated mitochondrial DLAT enzymes, there is also a loss of ironsulfur (Fe-S) cluster proteins, leading to proteotoxic stress [21,39,40,41]
162 In couples undergoing in vitro fertilization due to male infertility, giving the men 6 mg of melatonin daily was reported to reduce sperm DNA oxidative damage after 45 days and result in higher quality embryos
Actionable Takeaway If using a GLP-1 agonist for weight management, start at the lowest dose, titrate every ~4 weeks as tolerated, maintain nutrition/resistance training, and monitor GI tolerance, hydration, and moodunder clinician supervision with pharmacy-verified products
It isnt a drug or a medical treatment