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That portion of the preamble, which addressed reporting requirements and sanctions, appeared in the April 6, 2004 Federal Register (69 FR 17933)

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The skin, in particular, has its own antioxidant defense system that eliminates excess ROS through both enzymatic and non-enzymatic pathways, thereby maintaining redox balance and prevent the damage of ROS to cellular tissues ( Although ROS contribute to oxidative stress and inflammation, they are also essential for normal physiological functions