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1 , CD009461 (2013)

It is also possible that while heating is effective at disrupting protein shapes and eliminating enzyme activity, it does not eliminate ice nucleation activity as the proteins are twisted into new shapes that have ice nucleation sites, similar to the hypothesis that defects and aggregation of large proteins are a source of ice nucleation sites 55

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Mutant glutamate transport proteins are also associated with sporadic forms of ALS, further supporting the idea that elevated levels of glutamate-mediated excitation can kill motor neurons in ALS patients (Lin 1998