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Enhanced activity of PARP1 leads to excessive consumption of NAD+, which may adversely affect the integrity of the BBB (Zhan et al., 2023)

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(3) Vesicular displacement: Tyramine is transported into synaptic vesicles through vesicular monoamine transporter 2 (VMAT2), displacing norepinephrine (NE) from vesicular storage sites into the cytoplasm