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To view a copy of this license, visit About this article Cite this article Zhang, Z., Jiao, Y., Wang, Y

The treatment starts with zone mapping, application of a numbing gel if required followed by the delivery of ultrasound energy using a handheld machine into the targeted area in a grid manner

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reported that hyaluronic acid (HA)-modified MTX liposomes, delivered via microneedles, achieved significant improvement in imiquimod-induced mouse models by reducing key inflammatory cytokines (IL-17, IL-20, TNF-) and proliferation markers such as Ki-67, while also enhancing skin retention [118]