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No lethal dose has been established in animal studies, and the peptide appears to have wide safety margins

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Although some mysteries need to be clarified in the future, antioxidant compounds are useful neuroprotective agents in ameliorating brain damage in patients with refractory epilepsy

This latter finding is of particular interest, as rather than simply modifying the PDHc, glutarate formed a fatty acid conjugate that binds to the lipoylated catalytic arm of PDHc