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When the blood glucose level is high (a condition known as hyperglycemia), it can induce harmful changes in the brain, such as inflammation, oxidative stress, and damage to brain cells

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It bypasses first-pass hepatic metabolism which oral delivery does not allowing a greater proportion of the absorbed peptide to remain intact as it enters circulation.7 The olfactory pathway also provides a potential direct nose-to-brain route, bypassing the blood-brain barrier a property that has generated interest for neuropeptides and potential neurological applications