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Although our in vitro studies in lymphoid leukaemia cell lines suggest that the combination of polyphenols and topoisomerase II inhibitors may selectively enhance antitumour effects in tumour versus normal HSCs, future in vivo studies are needed to confirm that these effects are maintained in vivo

CBS and CSE have been reported to re-localise to mitochondria in response to hypoxia, a common feature of the tumour microenvironment, resulting in targeted H 2 S delivery that can stimulate ATP production and protect mitochondria from oxidative stress

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