Furthermore, administered caffeine doses varied significantly across the studies: 5 mg.kg -1 [34], 10 mg.kg -1 [32, 33, 39], 12.5 mg.kg 1 [42], 20 mg.kg 1 [39], 25 or 50 mg.kg 1 [42], 60 mg.kg -1 [39], and 200 mg.kg -1 [37]
As an important component of regulating metabolism and immune homeostasis, the vagus nerve can regulate WAT content through the central nervous system to control sympathetic peripheral muscle bundles, and can also regulate the release of GSH and NO to enhance antioxidant capacity and prevent ferroptosis (103)
In addition, a number of clinical trials investigating the effectiveness and safety of administering melatonin to people with MS have been conducted by Skarlis and Anagnostouli (2020)
therefore, also termed as PACE (Paired basic AA Cleaving Enzyme)