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Cyt c further binds to apoptotic protease-activating factor 1 (APAF1), causing activation of caspase-9 (Monian and Jiang, 2012

These observations underscore an important therapeutic implication for MASLD, showing that the timing and disease stage may be critical for maximizing the protective effects of GSH depletion, with the greatest benefit likely occurring during early, lipogenesis-driven phases of MASLD progression