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Furthermore, melatonin combined with a ketogenic diet overcomes drug resistance to cisplatin and vincristine in BC-bearing mice by inducing apoptosis, inhibiting angiogenesis, lowering blood glucose, increasing ketone bodies, and downregulating resistance genes, achieving cure rates up to 70% 168

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In patients with diabetic retinopathy, abnormal carnitine metabolism may exacerbate oxidative stress and inflammation in the retina and promote the development of the disease [317]