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)) of control aqueous and experimental solutions enriched with selenium

There is growing consensus regarding their pathophysiology and management, but more work is needed to elucidate the relationships between irAEs and treatment outcomes, specific biomarkers that clinch an irAE diagnosis, the impact of tailored immunosuppression on ICI outcomes, and the management of steroid-refractory irAEs

ChIP of GPX4 promoter Chromatin immunoprecipitation (ChIP) was performed using a Chromatin Immunoprecipitation Assay Kit (ChIP Assay Kit, P2078, Beyotime) according to the manufacturers instructions

We subsequently established a cellular hypoxia model using cobalt chloride (CoCl) and validated the effects of BPC157 under these conditions