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While the IOM had based B12 needs on the amount required to correct hematological parameters for people with pernicious anemia, the EFSA had almost 20 more years of research to draw on, and concluded that the most suitable approach was basing needs on biomarkers (serum B12, holotranscobalamin, MMA, and homocysteine)

Continuous Expansion of Research and Application Scenarios At present, its application has been extended to fields such as cellular antiaging and neuroprotection

Some protocols involve longer continuous use for 6-12 months with ongoing monitoring

And the specific adjustments that separate mediocre results from optimal outcomes