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(B-F) After 24h in culture with either 250uM melatonin or vehicle control the concentrations of IL-5 (B), IL-13 (C) , IL-9 (D) IL-10 (E) , and IL-6 (F) was determined by LEGENDPlex assay

However, a Cochrane systematic review encompassing five randomized controlled trials (415 women) found insufficient very low-quality evidence to support its effectiveness in improving clinical pregnancy rate (RR 1.38, 95% CI 0.91 to 2.10), live birth rate, overall pain, miscarriage rate (Peto OR 1.99, 95% CI 0.20 to 19.37), or endometriosis recurrence (RR 0.84, 95% CI 0.30 to 2.36), highlighting the need for higher-quality trials (65)

VFK was the principal investigator for the research grant that supported this study

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