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Despite earlier beliefs of AAVs being free of insertional mutagenesis, some studies suggest that AAV has a propensity to integrate randomly into the genome at double strand breaks (DSBs) [147], leading to tumorigenesis and liver cell hyperplasia in animals [148]

A peptide that varies in potency between batches can produce fluctuating hormone levels and unclear outcomes

Fermentation in the gut yields SCFAs, which lower intestinal pH, inhibit harmful bacteria, and enhance intestinal barrier function and immunomodulation (Lin et al., 2021

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