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Also, a recent preclinical study reported that an acute systemic administration of ciproxifan palliated some sociability impairments and stereotypic behavior in an animal model of VPA-induced ASD in mice (Baronio et al., Figure 2 Current pharmacological intervention Based on the aforementioned abnormalities in genes as well as various neurotransmitter systems, studying the effects of a given drug on core symptoms in ASD is very challenging

Consequently, targeting the PI3K/Akt signaling pathway may play a pivotal role in overcoming chemoresistance

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