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DATSmediated cancer cell proliferation inhibition is related to cell cycle arrest, including human hepatoma cells (Wu et al., 2004), gastric cancer cells (Ha et al., 2005), colon cancer cells (Hosono et al., 2005), prostate cancer cells (HermanAntosiewicz & Singh, 2005
A further hypothesis is that ME/CFS could include misdirected immune responses to the initial infection, resulting in a chronic autoimmune disease with molecular mimicry (the hit and run hypothesis) (85)
Chronic exposure to these factors leads to sustained immune cell activation, which in turn drives mitochondrial dysfunction and elevated ROS levels further amplifying immune activation and inflammatory signaling (Kaliszewska et al., 2021
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