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Pregnant women should avoid it for the same reason.20 Drug interactions: Sermorelin may interact with certain prescription and over-the-counter medicines, including but not limited to glucocorticoids, insulin, muscarinic antagonists (e.g., atropine), thyroid medications, medications that contain or release somatostatin, and aspirin.20 Underactive thyroid: Having an underactive thyroid may interfere with sermorelins effects