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After 40, melatonin production declines measurably , pineal calcification accelerates, and sleep architecture progressively deteriorates

And then ever since then, things slowly kind of went downhill

Moreover, a cross-cancer GWAS among patients receiving ICIs identified three common variants that are associated with all-grade immune-related adverse events, the most consistently replicated of which was an intronic variant in IL7 that is predictive of increased lymphocyte stability after ICI initiation as well as improved OS 320

A key antioxidant that plays a major role in the maintenance of the cellular redox state and reduces oxidative stress