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[DOI] [PMC free article] [PubMed] [Google Scholar] 312.Sanmartn C., Plano D., Sharma A.K., Palop J.A

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The binding of T3 to TRs induces a conformational change in the receptor, which allows the receptor to bind to thyroid hormone response elements (TREs, specific DNA sequences) in the promoter regions of target genes (Simons 2003)