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Given that both diet composition and adiposity can each substantially impact the gut microflora in obese mice 24 , we conducted a secondary endpoint study using animals given the same series of diets to test the hypothesis that NNMTi treatment combined with LD, but not LD alone, shifts the cecal microbiome profile of obese animals to be similar to age-matched LD controls that were never given a high-fat diet
The leap from animal model findings to confirmed human benefit is significant, and many compounds that show promise in preclinical research do not translate successfully to human medicine
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the researchers stressed that more studies are needed, and other research has been mixed
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