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The other injuries were initiated at periphery (i.e., nerve transection [79], abdominal aorta occlusion [82], tumor cachexia [11], or application of neurotoxin [69,80], distinctive muscle relaxants [81], neuroleptics [68,70], L-arginine [86], L-NAME [70,86], alcohol acute and chronic intoxication [63,64], and electrolytes disturbances [54,83,84,85])

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The first and main effect is related to the pressor effect of tap water ( The second mechanism may be in relation to the absorption of water and its effect on plasma volume ( Since water increases CO and blood pressure, we observed an increase in oxygen delivery