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In mammals, HRD1 mediates K48-linked degradation of BMAL1, regulating transcriptional activity of downstream circadian genes ( Other polyubiquitin linkages, like K29 and K11, may modulate clock function without directly inducing degradation or indirectly via influencing pathways involved

7.2 episodes per 100 patient-years of exposure, respectively)

If liver biopsy is performed, the hallmark histopathological feature is accumulation of coarse brown-black granules typically seen on hematoxylin and eosin staining, predominantly within the cytoplasm of centrilobular (zone 3) hepatocytes, sparing the periportal areas

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