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Previous evidence demonstrated that cortistatin is produced by primary sensitive neurons that innervated laminae IIII of the spinal cord dorsal horn and by GABAergic interneurons localized in laminae IVV and that exert inhibitory actions on the sensitization of spinal secondary nociceptors [22]

This comprehensive matrix-enhancing profile distinguishes GHK-Cu from selective collagen-stimulating agents, offering broader regenerative effects across multiple matrix components

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