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doi: 10.1016/j.ddtec.2015.06.003 67 SunL.SongF.ShiN.LiuF.LiS.LiP.et al

Sacco R, Eggenhoffner R, Giacomelli L

Concurrently, IGF-1, as a crucial synergistic factor for E 2 and progesterone, has been demonstrated in uterine fibroid studies to activate this pathway by upregulating the phosphorylation levels of PI3 K, Akt, and mTOR