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The second mechanism by which glutathione causes lightening of skin is inhibition of transfer of tyrosinase to premelanosomes for melanin synthesis.[] The third mechanism of tyrosinase inhibition is through its antioxidant effect as it scavenges the free radicals generated in the epidermis following UV light irradiation

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However, these cells convert rapidly to a pro-regenerative phenotype (Ly6C lo ) [103] that is essential for recovery by removing cell debris and promoting regeneration [104, 105]

These enzymes sit on the outer side of the membrane and break GSH down, generating glutamate and cysteinylglycine, which can be further broken down into cysteine and glycine