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Numerous preclinical reports have highlighted the ability of curcumin to restore reduced GSH levels and the activities of GSH-related antioxidant enzymes in the myocardium after exposure to cardiotoxic factors, for example, DOX, I/R, diabetes, hyperthyroid conditions, and copper sulfate [184,185,186,187,188]
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Loss-of-function mutations or downregulation of genes encoding arGSTs result in strongly decreased accumulation of anthocyanins ( 1 ) in a wide range of plants 19,20,21,22,23,24,25,26,27,28 , including reduced fruit colouration in cultivated Fragaria vesca (strawberry) through transient knock-down of reduced anthocyanins in petioles ( RAP ) 20 or white Prunus persica (peach) flowers caused by an arGST encoding regulator involved in anthocyanin transport ( Riant ) gene with a 2 bp insertion leading to a premature stop codon 21
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