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L.WarraichS

4.2 Lack of specific biomarkers and translational limitations of therapeutics The clinical translation of ferroptosis-targeted strategies is bottlenecked by two critical barriers: the absence of specific, standardized biomarkers for ferroptosis in renal tissues and biofluids, and the suboptimal pharmacokinetic and safety profiles of current ferroptosis modulators

Additionally, we have identified varying degrees of interference in experimental studies on ammonia metabolic reprogramming

Long-term consequences of NNMT inhibition are unknown Dosing is not established : No human dosing protocol has been validated