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In contrast, DFP treatment significantly decreased Fe 2+ levels in optic nerve tissue, downregulated TFR1 and Iba-1 expression, and inhibited iron deposition, ferroptosis, microglial activation, and astrocyte proliferation, thereby reducing myelin loss and optic nerve damage in MS mice (Rayatpour et al., 2022)

Moreover, both peptides have shown potential benefits for angiogenesis, the recovery of muscle injuries, and wound healing

Moreover, tissue-resident type A synoviocytes (macrophage-like) are key mediators of innate immune responses and interact with FLSs to potentiate inflammatory cascades, further contributing to cartilage destruction and joint pain