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Host-specific response to HCV infection in the chimeric SCID-beige/Alb-uPA mouse model: role of the innate antiviral immune response

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In addition, Sirt3 expression deficiency leads to superoxide accumulation, impaired spindle assembly, and mitochondrial dysfunction, including uneven mitochondrial distribution, decreased mitochondrial potential, and reduced mitochondrial DNA content in senescent oocytes [88]