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This process not only directly generates excessive ROS by initiating the non-enzymatic Fenton reaction but also enhances the activity of lipoxygenase (ALOX) or EGLN prolyl hydroxylases (also known as PHD) [1, 19, 20]

EEG has periodic slow and sharp waves (61)

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Mental fatigue was also measured using EEG spectral changes in the theta and alpha waves in the brains frontal and occipital cortical regions, where slow wave activity increases in mentally fatigued individuals [120,121,122], suggesting that as mental load increases, the brain loses its capacity to cope with it, thus slowing down brain activity