Common experimental arenas include: Telomere and cellular aging models: Evaluation of telomerase activity, telomere length dynamics, replicative lifespan, and senescence markers in cell culture and animal studies
Ge, Z, Leighton, J, Peng, X, Sun, Y, Yao, F, Liu, Y, Zhang, W, Akbani, R, Broom, BM, Ju, Z, Kanchi, RS, Korkut, A, Li, J, Ling, S, Liu, W, Lu, Y, Mills, GB, Uppore Kukkillaya, AR, Weinstein, JN, Zhang, J, Liu, X, Wang, L , Carvalho, AL, Fregnani, JG, Reis, RV, Scapulatempo, CN, Ajani, JA, Behrens, MC, Bondaruk, J, Broaddus, R, Czerniak, BA, Esmaeli, B, Fujimoto, J, Gershenwald, JE, Guo, CC, Lazar, A, Logothetis, CJ, Meric-Bernstam, F, Moran, C, Ramondetta, LM, Rice, DC, Sood, AK, Tamboli, P, Thompson, T, Troncoso, P, Tsao, A, Wistuba, II, von Deimling, A, Piwnica-Worms, H, Ma, L, Liang, H
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Suppression of IGF-1 signaling is a potential therapeutic approach, because the IGF1R inhibitor in combination with castration inhibited PCa growth in rodent models of bone metastasis and subcutaneous xenografts (61, 62)