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doi: 10.3390/biomedicines10112683 130 IwabuchiTYoshimotoCShigetomiHKobayashiH

j l ) Representative whole dorsal striatal images of NPY immunofluorescence from Trkb Penk-WT control ( j ), Trkb Penk-KO mutant injected at 3 M with Gsto2 -shRNA ( k ) or scrambled-shRNA ( l ) in the striatum and analysed at 8 M

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Steric hindrance from the increased side-chain volume of E14 Cagri and R17 Cagri promotes a shift of the -helix of Cagri away from ECL2 and a slight expansion of the peptide binding pocket at the extracellular side of the CTR TM domain, relative to those observed with rAmy/San385-bound AMYR complexes