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The expansion of the polyQ tract and change in conformation of ATXN3 was reported to alter transcriptional activity in cells by impairing repressor activity, when compared with wild-type ATXN3, of the MMP-2 gene promoter [115], and by reducing capability to activate FOXO-mediated SOD2 expression during oxidative stress [116]

DNA Synthesis: Vitamin B12 is essential in the production of nucleotides, the building blocks of DNA, and is thus critical for normal cell growth, replication, and repair

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