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Most of these agents did not reach the clinical setting, mainly because of the high risk of adverse effects [24]

Using stable-isotope tracers, we recently confirmed that obesity-associated glycine deficiency compromised the synthesis and clearance of endogenous and xenobiotic acylCoAs as acylglycines 3

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Patients with a first-degree family history of BRCA-associated breast/ovarian cancer, Lynch syndrome-related colorectal cancer, or familial adenomatous polyposis should be counseled that the VEGF-stimulating profile of BPC-157 has not been studied in genetically high-risk populations