Luteolin promotes long-term potentiation and improves cognitive functions in chronic cerebral hypoperfused rats
In the first step, cysteine and glutamate are linked in a reaction catalyzed by the -glutamylcysteine synthase (-GCS) to form -glutamylcysteine
Seiler A, Schneider M, Frster H, Roth S, Wirth EK, Culmsee C, Plesnila N, Kremmer E, Rdmark O, Wurst W et al (2008) Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death
rosea possesses antioxidant and mitochondrial-protective properties, effectively scavenging reactive oxygen species (ROS), stabilizing mitochondrial membrane potential, and augmenting adenosine triphosphate (ATP) synthesis, which collectively uphold neuronal bioenergetics during conditions of physiological stress (57)