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The main cellular sources of ROS are (1) mitochondria, where electron-transport-chain (ETC) leads ROS production through leakage of electrons during oxidative phosphorylation, (2) NADPH oxidases (NOXes), which generate superoxide and hydrogen peroxide (H 2 O 2 ) through transferring electrons from NADPH donors to oxygen, regulating both immune response and homeostatic ROS signalling (3) peroxisomes, which produce H 2 O 2 as a byproduct during breakdown of metabolic reactions such as breakdown of fatty acids and (4) xanthine oxidase, which generates superoxide and H 2 O 2 as a byproduct of oxidative hydroxylation of hypoxanthine in purine metabolism

The important question for this page is how much of that biology has actually been shown to translate into growing hair on a human head, and the answer, set out below, is: much less than the marketing implies

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