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Vitamin B12 Intramuscular (IM) Injections have become a popular method of supplementing this essential nutrient, particularly for individuals with B12 deficiency or those seeking to address specific health concerns

Nevertheless, use of metformin may decrease vitamin B 12 status: a meta-analysis of four short-term intervention trials (up to 4 months duration) in patients with type 2 diabetes found that metformin use decreased serum cobalamin concentrations by 57 pmol/L, which could have clinical implications if such patients have suboptimal vitamin B 12 status (146)

Pregnancy Support For expectant mothers (with healthcare provider approval), B12 provides important support: Essential for fetal brain and nervous system development Helps prevent neural tube defects Supports maternal energy during pregnancy Contributes to healthy red blood cell production Note: Always consult with your prenatal care provider before starting any supplement

In the Pune cohort, infants of mothers who were in the lowest decile of vitamin B-12 concentrations at 28 wk of gestation performed less well on tests of attention and memory compared with infants born to mothers of the highest decile (38)