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Banerjee, S., Mukherjee, S., Mitra, S., & Singhal, P

Common prodrug-converting enzymes used in engineered bacteria include cytosine deaminase for 5-fluorocytosine (5-FC) [75, 335], various nitroreductases for CB1954 [336], the quinone reductase yeef for CB1954 [337], -glucuronidase for glucuronide prodrugs or related precursors [338], purine nucleoside phosphorylase for 6-methoxypurine 2-deoxyriboside (MoPdR) [339], herpes simplex virus thymidine kinase for ganciclovir [340, 341] and Neisseria meningitidis type I nitroreductase (NmeNTR) for PR-104A [342]

Topical use for skin texture, fine lines, and wound healing generates consistent positive anecdotes

doi: 10.1210/endo-129-3-1363 310 MurckHSongCHorrobinDFUhrM