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Ms all del efecto sobre el EEG y el sueo, la revisin de Graf y Kastin documenta que el material tipo DSIP se distribuye en cerebro, rganos perifricos y plasma, y se ha asociado con la modulacin de niveles de neurotransmisores, patrones circadianos/locomotores y niveles hormonales (incluidos ejes relacionados con el HPA), con una curva de respuesta a dosis y tiempo de tipo no lineal (forma de U) (PMID 6145137)