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This selectivity was demonstrated in the landmark study by Raun et al.: at doses producing a maximum increase in GH, ipamorelin did not alter plasma cortisol or prolactin levels (Raun et al., Eur J Endocrinol 1998)

[10] Ipamorelin, based on experimental data, might also elevate growth hormone secretion levels to approximately 80 mIU/l, which appears to be 60 times higher than the levels observed following test model exposure to a placebo

The study characterized the degradation kinetics of AOD9604 in biological matrices and identified the specific cleavage products generated by endogenous proteases