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Plasma metabolic profiles in SS versus SC patients who have not been recently transfused Individuals with SS genotypes represented approximetely 73% of the cohort in this study and showed distinct clinical 9 , 24-28 and metabolic phenotypes ( Online Supplementary Figure S1 ) compared to patients with other genotypes

Glutamine availability up-regulates expression of the amino acid transporter protein asct2 in hepg2 cells and stimulates the asct2 promoter