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AOD-9604 also appears in cartilage repair research (originally investigated for osteoarthritis before pivoting to obesity), because the hGH fragment retains some regenerative signaling without the proliferative risks of full hGH

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Patients who already have exceptionally high pyridoxine levels or signs of pyridoxine toxicity (such as sensory neuropathy) should not continue to receive high-dose supplementation until those symptoms resolve

demonstrated that AOD-9604 stimulates production of type II collagen and aggrecan in chondrocytes, key components of the cartilage matrix