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In preclinical models, DSIP is applied to investigate how peptide signaling contributes to stress adaptation, neuroendocrine balance, and systemic homeostasis under varying physiological conditions

82004434), Special Training Program for Outstanding Young Scientific and Technological Talents (Innovation) of China Academy of Chinese Medical Sciences (No

For experiments involving alterations to the culture medium, cells were seeded in regular RPMI 1640 with 5% dialysed FBS (Gibco, 26400044) and 1% penicillin and streptomycin

In certain embodiments, any controlled-release otic formulation described herein increases the exposure of an active agent and increases the length of time that the concentration of the active agent is above C min by about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, or about 90% compared to a formulation that is not a controlled-release otic formulation