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4 Optimum positive attributes of chitosan and its analogs in terms of physicochemical, structural and operational aspects, along with minor downsides Chitosan and its derivatives have drawn considerable interest from various fields because of their distinctive physical, structural, and operational features (Wang et al., 2020b)

Pigmented fungiform papillae, first reported by Leonard in 1905, are characterised by asymptomatic discrete hyperpigmentation confined to fungiform papillae of tongue

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a thin, fibrous, extracellular matrix of tissue that separates an epithelium from its underlying tissue), as well as protecting other tissues in the body (Phang et al